Modulation of warfarin sodium into warfarin potassium for patients with hypertension
- OLCIAS
- Mar 14, 2023
- 2 min read
Updated: Apr 4, 2023
Title Talk: Modulation of warfarin sodium into warfarin potassium for patients with hypertension
Author:
Al-Baraa Akram Clinical Pharmacist and Researcher
De montfort University in Leicester
United Kingdom EmailID: albraaakram94@gmail.com
Volume: Drug Discovery 2023_CN31_AA01
Abstract:
Warfarin is an oral anticoagulant drug that has a prolonged duration of action with delayed onset of action; its chemical structure contains sodium atoms, which may be hazardous to hypertensive patients. To solve this problem, sodium atom can be substituted with potassium or lithium atom which can help the patient to relieve hypertension in addition to it essential role as an anticoagulant. Another advantage of this preparation is that it can be used as an antidote against digitalis toxicity, but the warfarin interactions with other drugs are still the same as a cytochrome P450 inhibitor.
Warfarin reduces blood clotting by inactivating vitamin K epoxide reductase, which activates vitamin K1, the main component in the blood clotting process. Without sufficient vitamin K1 activation, clotting factors II, VII, IX and X have decreased clotting ability. The anticlotting protein C and protein S have also inhibited, but to a lesser degree. A few times are required for the clotting process, and these effects can take about five days. Additionally, because this process requires enzymes like VKORC1, patients who take warfarin with polymorphism of these enzymes can require adjustment as genetic factors should be taken into consideration, thus may require lower doses.
Biography:
Al-Baraa Akram is a clinical pharmacist and researcher. He had his bachelor degree in clinical pharmacy from faculty of pharmacy-Assiut University in Egypt and he had his master degree in pharmaceutical biotechnology from De montfort University in Leicester in United Kingdom. He published 11 journal articles and 15 books, he has also 7 patents. He works as a pharmacist in Egypt for more than 6 years and he is also an editor in neurology and neuro-rehabilitation journal. He participated in many international conferences as a speaker and worked as a demonstrator in faculty of pharmacy-pharmacognosy department in 6th October University in Egypt and awarded the best scientific research in Arab republic of Egypt in 2017 from Aswan University and he awarded scholarships in Russia, United Kingdom and Germany.
He participated in many international conferences as a lecturer in France and Italy.
