Neuroprotective Effect of Inosine against Aluminium Chloride (AlCl3) Induced Experimental Dementia..
- OLCIAS
- Mar 14, 2023
- 3 min read
Updated: Apr 4, 2023
Title Talk: Neuroprotective Effect of Inosine against Aluminium Chloride (AlCl3) Induced Experimental Dementia & Mild Cognitive Dysfunction in Rats
Author:
Dr. Mohit Agrawal Assistant Professor at Department of Pharmacology School of Medical & Allied Sciences K.R. Mangalam University, Gurugram, Haryana India EmailID: mohitagrawalmohu@gmail.com
Volume: Drug Discovery 2023_CN31_AA02
Abstract:
Alzheimer disease is a neurodegenerative disorder that is identified by the loss of memory, cognitive function and muscle coordination and various memory related task. Various studies throughout the decades have shown that oxidative stress plays one of the key roles in initiating the Alzheimer Disease. As the oxidative stress is majorly caused by the reactive oxygen species it is proven in various studies that the antioxidants are quite effective against the ROS to induce the oxidative stress in the brain the AlCl3 chemical is used as it is proven that AlCl3 model for the inducing dementia is a neurotoxic metal that can cause neurodegeneration by oxidative stress. As the Inosine is one of the naturally occurring potent antioxidant it can be quite effective against the ROS and protecting the brain from the oxidative stress and could help in improving the various memory and motor dysfunctions. In this study we have selected 36 Wistar rats divided in a 6 group each containing 6 rats each weighing 150gm-200gm. Various behavioural analysis were conducted at every week which were, Morris Water Maze, Novel Object recognition Test, open field test and Actophotometer. And the day of 30th day the brain was isolated from the rats specifically the cortex and the hippocampus region of the brain for various biochemical estimations which are Lipid Peroxidation, Glutathione Reduction (GSH), Superoxide Dismutase and Nitrite Estimation in the Brain. Inosine might be neuroprotective candidate against aluminium chloride induced Alzheimer’s diseases.
Biography:
Dr. Mohit Agrawal is currently working as an Assistant Professor at Department of Pharmacology, School of Medical & Allied Sciences, K.R. Mangalam University, Gurugram, Haryana, India. He has done B.Pharm, M.Pharm (Pharmacology) from MRS Punjab Technical University, Punjab, India & Ph.D. from DIT University, Dehradun (UK). He has an outstanding academic record with many International & National Publications in reputed journals. He has supervised M.Pharm Students for their research work successfully & also supervised more than 50 projects on B.Pharm level in the field of clinical research & Pharmacovigilance. He has also awarded the Travel Grant/Fellowship worth 05 Lakh for the Alzheimer’s Association International Conference® 2022 (AAIC®) which was hosted in San Diego, California, United State of America (USA). He has written 01 International book entitled “Herbal Medications for Neurological Disorders” Published by Walnut International Publishers (USA & UK).
His major area of Research interest in Pharmacological investigation in the areas of Alzheimer's disease, vascular dementia, Parkinson's disease, Schizophrenia, Huntington Disease, Psychological stress, etc. He has a vigorous background in Pharmaceutical Research & related field. He has a touch base with others Pharmaceutical Sciences & Technology professionals to update on latest principles. He has published many Research & Review article in International journals like Elsevier, Springer nature, Taylor & Francis, CRC press, Florida, USA. He has written many book chapters published by Elsevier science USA, Springer nature and Taylor & Francis, CRC press (London). He has Published 02 Indian Patent IPR, Govt. of India. He has attended more than 20 conferences & presented poster on National & International level. He has got Best oral presentation award entitled “Neuroprotective potential of fingolimod against Scopolamine induced experimental dementia in Wistar rats” in international conference organized virtually by Manipal college of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka. He has got several awards in entrepreneurship in emergic economics organized by Entrepreneurship Development cum-business incubation cell, University of Business School, MRSPTU, Bathinda (Punjab). He has Remarkable ability to lead, Guide, direct, develops & motivate students at all the levels & superior organizational & management levels, He has Ability to work in a team as well as individually.
