Brain Injury

International Live Conference on

September 17, 2022

Awareness, Prevention and Treatment of Brain Injuries

OLCIAS is pleased to announce at it's annual International Live Conference on Brain Injury which will be taking place on September 17, 2022

This conference brings together researchers and clinicians from industry, academia, the military, and government to present ground-breaking research in a variety of areas related to Brain Injury.

 

The death or degeneration of brain cells is referred to as neurotrauma, brain damage, or brain injury (BI). There are many different internal and external variables that can cause brain damage. In general, the term "brain injury" refers to severe, uniform trauma-related harm. 

 

Traumatic brain injury (TBI) after physical trauma or head injury from an external source is a common category with the highest number of injuries, and acquired brain injury (ABI) is used appropriately to distinguish brain injuries that occur after birth from injury, from a genetic disorder (GBI), or from a congenital disorder (CBI).  While focal and diffuse brain injuries indicate the severity and localisation, primary and secondary brain injuries highlight the mechanisms involved.


This event provides a special opportunity for various stakeholders to present original research and analysis aimed at providing a full picture of the progress towards better diagnosis, treatment, and long-term care for Brain Injury survivors. At this annual event, physicians, nurses, neurosurgeons, scientists, and drug/diagnostic developers from all over the world network and learn from one another. Focus areas include:
 

  • Traumatic Brain Injury

  • Concussion

  • Coma

  • Brain Dead

  • Critical Care

  • Current Clinical Management of Brain Injury

  • Outcomes Research

  • Recovery, Regeneration and Plasticity

  • Preclinical/Clinical Development Models/Design

  • Emerging Tools for Diagnosis/Assessment of TBIs

  • Neuroimaging Research and Practice

  • BI Therapeutic Preclinical/Clinical Candidates

  • Advances and Opportunities for TBI Biomarkers

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Adejoke Elizabeth Memudu and Deloraine Dennis
Adejoke Elizabeth Memudu and Deloraine Dennis

A proposed mechanism of reversal of established Traumatic Brain Injury-Induced and Anxiety-Like Behavior in Rats using natural product: An experimental study of honey

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Adejoke Elizabeth Memudu and Deloraine Dennis
Adejoke Elizabeth Memudu and Deloraine Dennis

A proposed mechanism of reversal of established Traumatic Brain Injury-Induced and Anxiety-Like Behavior in Rats using natural product: An experimental study of honey

press to zoom
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A proposed mechanism of reversal of established Traumatic Brain Injury-Induced and Anxiety-Like Behavior in Rats using natural product: An experimental study of honey
 

Traumatic Brain Injury (TBI) which is a damage to brain caused by an external force, can lead to neurodegeneration and it is implicated as a risk factor for neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and neuropsychiatric disorders, like depression, anxiety. Presently, there are no therapeutic measures to avert the development of post-traumatic anxiety once it has developed, this is because of lack of understanding of the exert underlying pathophysiology for developing post-traumatic anxiety. Recent research suggests that chronic neuroinflammatory responses to TBI and activation of oxidative neuronal damage may play a role in the development of post-traumatic anxiety in rodent models. The use of natural products with strong antioxidant potential have been reported to avert neuroinflammation and oxidative tissue damage. Hence, honey is study to evaluate its potential to ameliorate possible post-traumatic stress and anxiety in weight drop animal model of TBI. This study used twenty adult male Wistar Rats divided into four groups (A-D) viz: Control, honey treated, honey treated

TBI model. The serum activity of neuroinflammatory biomarker Malondialdehyde (MDA) and antioxidant enzyme Superoxide dismutase, Catalase, and Glutathione synthase were analyzed. Neurobehavioral paradigms for motor function test via Rotarod and Elevated Plus Maze (ELP) test for anxiety levels were carried out. Results obtained showed that TBI model presented with a statistically significant reduction in balance co-ordination and mean time spent on the wheel @p<0.05 in contrast to an increase in the TBI and honey treated groups. Anxiety level using the ELP showed the TBI has anxiety which was declined in the honey treated group. Serum activity of MDA in TBI model increased with a decline in SOD, CAT and GSH activities as compared with the control and honey treated group. Hence TBI can induced post traumatic anxiety by activating mechanism of neuroinflammation, oxidative tissue damage that results in changes in neuron circuits presenting in anxiety like behaviour which is reversed by antioxidant potential of honey a natural product.

Deloraine Dennis

Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine

Bingham University, Karu, Nasarawa State, Nigeria

And

Adejoke Elizabeth Memudu

Department of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences

Edo University, Iyamho, Edo State, Nigeria